What is Gene Ontology?
Gene ontology is the process of determining where a specific protein functions, its biological process, and its molecular function. All three of these categories give vital information for learning about a protein's role within the organism. By utilizing gene ontology the basic understanding of the protein can begin!
What is EFHC1's Gene Ontology?
Using the GeneOntology database, information was found for the EFHC1 protein.
EFHC1 was found to be located within ependymal cilia, trachea cilia, sperm flagellum, neuronal cell bodies and neuronal dendrites. EFHC1 is also found to be associated with the mitotic spindle during mitosis. Biological processes found for EFHC1 include calcium ion binding and positive regulation of the apoptotic process. Analysis: These findings indicate EFHC1's association with microtubules, due to the involvement in cilia, sperm, and neurons which all contain high levels of microtubule structures. The mitotic spindle is also a microtubule apparatus. Thus the gene ontology of EFHC1 points towards an involvement in microtubule structure, as well as calcium ion involvement which has been associated with the EF hand domain. |
References:
Image 1: http://www.geneontology.org/GO.cite.shtmlImage 2: http://nymag.com/thecut/2013/12/fighting-off-rivals.html
The Gene Ontology http://amigo.geneontology.org/amigo/search/bioentity?q=efhc1